Vol. 7, Issue 1, Part A (2025)

Urinary tract infection (UTI) is one of the most frequent causes of urolithiasis. Over the last 20 years, the prevalence of infected stone has changed significantly. Several studies have found the relationship between urinary stones and urinary tract infection. This study also explored the bacteriology and its relation with stone formers. This cross-sectional study was carried out in the department of urology, Sir Salimullah Medical College Mitford Hospital, for one-year period after ethical approval. A total of 55 patients who had UTI with urinary stones were included. After taking informed written consent, detailed clinical history and necessary investigations were carried out in each patient. Urinary stone was sent for chemical analysis. Data were collected in separated case-record form and analyzed by SPSS 24. Mean age of the study populations was 42.03±9.51 (SD) years with male predominance (65.5%). Among all, 15 patients (27.3%) were culture positive, wherein majority were gram negative bacteria (n=11, 73.3%). E. coli (53%) was the most common bacteria followed by Klebsiella (13.3%), Staphylococcus (13.3%) & Enterococci (13.3%). Most commonly found urinary stone was Calcium oxalate monohydrate (49.1%) followed by Calcium oxalate dihydrate (16.4%), Magnesium ammonium phosphate (14.5%), Carbonate apatite (10.9%), and Uric acid (9.1%). Calcium Oxalate Monohydrate (62.5%) was found to be the most common stone in E. coli positive patients. Overall, culture positivity had significant association with stone types (p<0.05). Meropenem (86.7%) & imipenem (80%) were the most sensitive antibiotics in response to the significant culture positive organisms where Ciprofloxacin (53.3%) & Cotrimoxazole (46.7%) were the most resistant antibiotics. Urine culture positivity is related with formation of urinary stone, and E. coli was the most prevalent microorganisms in UTI with urinary stone patients. However, further multicenter studies are warranted.